With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1011-40-1,2-Phenylthiazole-5-carbaldehyde,as a common compound, the synthetic route is as follows.
EXAMPLE 82.2.2-Trinuoro-l-(2-phenyl-1.3-thiazol-5-vnethanone (H2) Step 1: 2,2,2-Trifluoro-l-(2-phenyl-l,3-thiazol-5-yl)ethanol (Hl)A solution (0.15 M) of 2-phenyl-l,3-thiazole-5-carbaldehyde (1.0 eq.) and CsF (0.2 eq.) in DME was treated with CF3SiMe3 (1.5 eq.) and then stirred for 3 h at RT. The reaction mixture was quenched by adding IN HCl and stirred for 30 min. The mixture was diluted with EtOAc, the organic phase was separated, washed with sat. aq. NaHCO3 solution and dried (Na2SO4). Evaporation of the solvent under reduced pressure afforded the product as an yellow oil. MS (ES+) CnH8F3NOS requires: 259, found: 260 (M+H)+., 1011-40-1
As the paragraph descriping shows that 1011-40-1 is playing an increasingly important role.
Reference：
Patent; ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA; WO2007/93827; (2007); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica