298694-30-1, 4-Bromo-2-methylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A mixture of 4-bromo-2-methyl-thiazole (1.5 g, 8.52 mmol), 4-chloropyridin-2- amine (1 .3 g, 10.22 mmol) and CS2003 (6.92 g, 21 .3 mmol) in 1,4 dioxane(30 ml) was degassed with nitrogen for 20 mm. Pd2(dba)3 (0.389 g, 0.42 mmol) and Xantphos (0.24 g, 0.42 mmol) were added and the resulting mixture was stirred at 90 00 for 16 h. When cooled to rt the mixture was filtered through celite, concentrated and purified by preparative HPLC to give the product as a solid (600 mg, 31%). 1H NMR (400 MHz, DMSO-d6) 6 10.15 (s, 1 H), 8.15 (d, 1 H), 7.37 (s, 1 H), 7.03 (d, 1 H), 6.85-6.84 (m, 1 H), 2.61 (s, 3 H). MS ES+ m/z226 [M+H].
The synthetic route of 298694-30-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SPRINT BIOSCIENCE AB; LINDSTROeM, Johan; FORSBLOM, Rickard; GINMAN, Tobias; RAHM, Fredrik; VIKLUND, Jenny; (93 pag.)WO2019/38389; (2019); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica