With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2634-33-5,1,2-Benzothiazol-3-one,as a common compound, the synthetic route is as follows.,2634-33-5
General procedure: The acid 4 (5 mmol), EDC (1.2 g, 6.26 mmol), HOBt (0.9 g,5.88 mmol), NMM (1.2 mL, 10.74 mmol), and dichloromethane (10 mL) were mixed at ice-bath and stirred at 0 C for half an hour. 1,2-Benzisothiazol-3-one 1 (800 mg, 5.3 mmol) was added to NMM (1.6 mL, 14.32 mmol) in 10 mL of dichloromethane at 0 Ct hen the above mixture was added and stirred at room temperature overnight. After stirring overnight, the mixture was diluted with CH2Cl2, and then successively through washed with water, 5% KHSO4 solution, saturated NaHCO3 solution, and brine, the extract was dried with anhydrous Na2SO4 and evaporated under vacuum. The product was isolated by column chromatography (petroleum ether/CH2Cl2, 10:1) to yield the final compound. 4.2.19 2-(3-(2-Methoxyphenyl)propanoyl)benzo[d]isothiazol-3(2H)-one (23) Compound 23 was prepared through 3-(2-methoxyphenyl)propionic acid, obtained a white solid in 93% yield. Mp 149.5-150.7 C. 1H NMR (400 MHz, CDCl3) delta 8.00 (d, J = 8.0 Hz, 1H), 7.68 (t, J = 8.0 Hz, 1H), 7.51 (d, J = 8.0 Hz, 1H), 7.39 (t, J = 8.0 Hz, 1H), 7.25-7.17 (m, 2H), 6.89 (t, J = 8.0 Hz, 1H), 6.85 (d, J = 8.4 Hz, 1H), 3.82 (s, 3H), 3.47 (t, J = 7.6 Hz, 2H), 3.09 (t, J = 7.6 Hz, 2H). 13C NMR (101 MHz, DMSO-d6) delta 172.9, 163.5, 157.6, 141.4, 135.0, 130.2, 128.6, 128.1, 127.4, 126.5, 125.7, 122.5, 120.8, 111.1, 55.7, 37.5, 24.9. IR (KBr, cm-1): 1689, 1675. HRMS-ESI (m/z) calcd for C17H15NO3S [M+H+] 314.0851, found 314.0843.
The synthetic route of 2634-33-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Li, Zhenghui; Pan, Yang; Zhong, Weilong; Zhu, Yunpeng; Zhao, Yongle; Li, Lixin; Liu, Wei; Zhou, Honggang; Yang, Cheng; Bioorganic and Medicinal Chemistry; vol. 22; 24; (2014); p. 6735 – 6745;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica