With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3622-35-3,Benzo[d]thiazole-6-carboxylic acid,as a common compound, the synthetic route is as follows.
To a solution of benzo[d]thiazole-6-carboxylic acid (2.5 g,13.95 mmol) in anhydrous CH2Cl2 (30 mL) was added triethylamine(1.95 mL, 13.95 mmol). The mixture was stirred at 10 C and a solution of ethyl chloroformate (1.33 mL, 13.95 mmol) in CH2Cl2(3 mL) was added dropwise. The resulting solution was stirred at10 C for an hour before addition of N-methoxymethylamine(1.36 g, 22.32 mmol) and triethylamine (1.95 mL, 13.95 mmol). Themixture was stirred 1 h 30 at 10 C, quenched with water, andextracted with CH2Cl2. The combined organic layers were driedover MgSO4, filtered, and evaporated under reduced pressure. Purification of the residue was performed by alumina column chromatography using CH2Cl2 as eluent to give compound 6 (1.22 g,39%) as a pale yellow oil.1H NMR (300 MHz, CDCl3) d 9.10 (s, 1H, CHS), 8.35 (d, 1H,J 1.5 Hz, H7), 8.14 (d, 1H, J 8.7 Hz, H4), 7.86 (dd, 1H, J 8.7,1.5 Hz, H5), 3.55 (s, 3H, CH3O), 3.41 (s, 3H, CH3N). 13C NMR (75 MHz,CDCl3) d 169.0, 156.1, 154.4, 133.4, 131.2, 126.4, 123.0, 122.6, 61.1,33.7.
3622-35-3, The synthetic route of 3622-35-3 has been constantly updated, and we look forward to future research findings.
Reference：
Article; Moine, Esperance; Dimier-Poisson, Isabelle; Enguehard-Gueiffier, Cecile; Loge, Cedric; Penichon, Melanie; Moire, Nathalie; Delehouze, Claire; Foll-Josselin, Beatrice; Ruchaud, Sandrine; Bach, Stephane; Gueiffier, Alain; Debierre-Grockiego, Francoise; Denevault-Sabourin, Caroline; European Journal of Medicinal Chemistry; vol. 105; (2015); p. 80 – 105;,
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