With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.118452-02-1,2-Aminothiazole-4-carboxamide,as a common compound, the synthetic route is as follows.
To a solution of 2-chloro-6-(trifluoromethyl)benzo[d]oxazole (500 mg, 2.26mmol) in DMF (8.0 mL) were added 2-aminothiazole-4-carboxamide (323mg, 2.26mmol) and K2003 (937mg, 6.78mmol) . The resulting mixture was stirred at 100 00 for 3 h. TLC showed the reaction to be complete. The reaction mixture was poured in to ice water (5OmL). The solid precipitated was filtered and washed with water (5OmL) and dried by azeotropic distillation using toluene. Thus obtained solid was triturated with DCM (lOmL) followed by Et20 (lOmL) and dried under vacuum. The solid was further purified by prep HPLC to afford 2-((6-(trifluoromethyl)benzo[d]oxazol-2- yl)amino)thiazole-4-carboxamide as an off white solid. Yield: 30mg (4.0%); MS (ESl+) for CHNOS m/z 328.99 [M+H] LC purity 98.0 % (Ret. Time- 5.55 mm); 1H NMR (400 MHz, DMSO-d6): 13.02 (5, 1H), 7.96 (5, 1H), 7.88 (bs, 1H), 7.78 (5, 1H), 7.58-7.73 (m, 3H).
118452-02-1, The synthetic route of 118452-02-1 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; DISCUVA LTD.; MEO, Dr Paul; KHAN, Dr. Nawaz; (284 pag.)WO2018/37223; (2018); A1;,
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