14527-44-7, Methyl thiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
10231] Procedure:10232] Pd(OAc)2 (3.9 mg, 0.017 mmoles), [P(t-13u)3H] HF4 (10.0mg, 0.035 mmoles), 1-adamantanecarboxylic acid (18.4 mg, 0.10 mmoles), K2C03 (96.5 mg, 0.70 mmoles), methyl thiazole-5-carboxylate (50 mg, 0.35 mmoles), and methyl 6-bromonicotinate (113 mg, 0.52 mmoles) were added to a dried flask. The flask was fitted with a reflux condenser capped with a septum, evacuated, and purged with nitrogen (.-5 times). Dry toluene (1.7 mE) was added via syringe, and the reaction was stirred at 110 C. for 48 h. The reaction mixture was cooled and filtered through Celite, and the filtrate was concentrated under reduced pressure. The crude product was then purified by chromatography on silica (3% acetone in 1:1 DCMlhexanes) to afford the title compound (28 mg, 29%) as a white solid. ?H NMR (400 MHz, CDC13) 0 9.22 (s, 1H), 8.51 (s, 1H), 8.43 (dd, J=2.0, 8.0 Hz, 1H), 8.29 (d, J=8.0 Hz, 1H), 4.00 (s, 3H), 3.96 (s, 3H); ?3C NMR (100 MHz, CDC13) 0 172.7, 165.1,161.8, 153.6, 150.9, 149.7, 138.4, 131.7, 127.1, 119.6, 52.6, 52.6; HRMS (ESI) m/z 279.0439 [calc?d for C,2H,,N204S (M+H) 279.0435].10233] For experiments with mammalian cells, this compound was recrystallized from EtOAc to afford a whitecrystalline solid., 14527-44-7
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Reference：
Patent; WISCONSIN ALUMNI RESEARCH FOUNDATION; RAINES, Ronald T.; Vasta, James; (50 pag.)US2016/280701; (2016); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica