155559-81-2, 5-Fluorobenzo[d]thiazole-2-thiol is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: A mixture of 4?-demethylepipodophyllotoxin (DMEP) (400mg 1mmol) and SH-containing building blocks in dichloromethane (15mL) at 0C was mixed with 1mL of TFA as the catalyst. After stirring the reaction mixture for 2-3hat room temperature and maximal conversion was reached (3h, monitored by TLC), the resultant mixture was washed with saturated NaHCO3 (20mL¡Á2) and extracted with CH2Cl2 (45mL¡Á2). The organic layer was dried over MgSO4, and the solvent was evaporated to give a crude residue, which was purified by flash column chromatography (petroleum ether: dichloromethane: ethyl acetate, 3:2:1) to afford the target compounds. The purity of compounds was determined by HPLC with a thermo-C18 (250mm¡Á4.6mm, 5mum) column as the stationary phase and methanol-water (35:65) as the mobile phase at ambient temperature and a flow rate of 2.0mL/min., 155559-81-2
155559-81-2 5-Fluorobenzo[d]thiazole-2-thiol 2774531, athiazole compound, is more and more widely used in various fields.
Reference£º
Article; Zhang, Qing-Yun; Zhao, Wei; Tang, Ya-Jie; European Journal of Medicinal Chemistry; vol. 158; (2018); p. 951 – 964;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica