With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31785-05-4,Ethyl 5-amino-2-methylthiazole-4-carboxylate,as a common compound, the synthetic route is as follows.,31785-05-4
Add a solution of ethyl 5-amino-2-methylthiazole-4-carboxylate (120g; 645 mmol) and 2-fluoronitrobenzene (68 mL; 645 mmol) in dimethylsulphoxide [(1L)] to a 2L 3-necked RB flask equipped with reflux condenser, thermometer, mechanical stirrer. Add lithium hydroxide monohydrate (54 g; 1290 mmol) to the solution and heat at [50C] for 3 hours under nitrogen. Cool the purple solution and pour onto ice/water, allow to stir for one hour, filter and wash with water, dry at [50C] under reduced pressure to give 190 g (96%) as an orange solid: mass spectrum (m/e): 308 (M+1) [; 1HNMR (300MHZ, DMSO-D6,] ppm): [8] 1.25 (tr, 3H), 2.56 (s, 3H), 4.25 (q, 2H), 7.20 (m, [1H),] 7.78 (m, 2H), 8.20 (d, 1H), 11.42 (s, 1H, NH). [13CNMR] (75MHz, DMSO, ppm): [5] 24.4, 29.2, 71.2, 127.8, 132.5, 132.8, 137.8, 146.5, 147.0, 147.5, 160.2, 161.5, 173.7. Formula : C13H13N3O4S.
As the paragraph descriping shows that 31785-05-4 is playing an increasingly important role.
Reference：
Patent; ELI LILLY AND COMPANY; WO2004/14895; (2004); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica