With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.615-21-4,2-Hydrazinylbenzo[d]thiazole,as a common compound, the synthetic route is as follows.
615-21-4, In a three-neck reactor equipped with a thermometer,In a nitrogen stream,10.0 g (60.5 mmol) of 2-hydrazinobenzothiazole was dissolved in 150 ml of DMF.To this solution,39.4 g (121.0 mol) of cesium carbonate was added and the mixture was cooled to 0 C.,16.4 g (72.5 mmol) of iodoheptane was added dropwise over 5 minutes,After completion of the dropwise addition, the whole contents were stirred at 25 C. for 3 hours.After completion of the reaction, 1000 ml of water was added to the reaction solution,And extracted twice with 500 ml of ethyl acetate.After drying the organic layer with anhydrous sodium sulfate,Sodium sulfate was filtered off.After concentrating the filtrate with a rotary evaporator,The concentrate was purified by silica gel column chromatography (n-hexane: ethyl acetate = 85: 15)9.05 g of Intermediate P was obtained as a white solid (yield 56.9%).
The synthetic route of 615-21-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ZEON CORPORATION; SAKAMOTO, KEI; OKUYAMA, KUMI; SANUKI, KANAKO; (77 pag.)JP2017/206554; (2017); A;,
Thiazole | C3H3NS – PubChem
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