288-47-1, As the paragraph descriping shows that 288-47-1 is playing an increasingly important role.
288-47-1, Thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Preparation 2A; 2-Bromoacetylthiazole; The following is a large-scale adaptation of the Dondoni procedure cited above. A solution of bromoacetyl bromide (57.6 g, 0.286 mol) in dry DCM (100 mL) was added at 0-60C to a stirred solution of 2-trimethylsilylthiazole (37.4 g, 0.238 mol) in DCM (300 mL). After 2h at 0 0C, aqueous saturated NaHCO3 (1 L) was added and the resulting mixture was extracted with DCM (2 x 500 mL). The extracts were stirred with decolorizing carbon (Darco KB, 10 g) and filtered through Celite, and concentrated. The residue was purified by SGC (1.2 kg silica, 1:3 to 1:1 DCM-hexanes) giving 25.2 g of colorless crystalline solid (41%). 1H NMR (CDCI3, 400 mHz) delta 8.02 (d, 1H, J = 3.3 Hz), 7.74 (d, 1H, J = 3 Hz)1 4.69 (s, 2H). An alternate preparation was also achieved as follows. A solution of n-butyllithium (13.1 mL of 2.5 M in hexanes) was added at – 78 0C to a stirred solution of 2-thiazole (2.66 g, 31.25 mmol) in ether (26 mL). After 15 mi?, methyl bromoacetate (3.11 mL, 32.8 mmol) was added giving a light brown slurry which was warmed to RT and treated with acetic acid (3.6 mL) . Water (50 mL) and ether (30 mL) were added and the ether layer was separated, dried, and concentrated. The residue was suspended in hexanes (50 mL) at reflux and the hexanes decanted from a heavy oil. This was repeated and the hexanes combined and concentrated giving 4.9 g of light yellow needles (76%) having NMR identical to that described above plus minor impurities which could be removed by one trituration with 10 mL hexanes at RT.
288-47-1, As the paragraph descriping shows that 288-47-1 is playing an increasingly important role.
Reference：
Patent; PFIZER PRODUCTS INC.; WO2008/4117; (2008); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica