The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (R)-2,2′-Bis[bis(4-methoxy-3,5-dimethylphenyl)phosphino]-4,4′,6,6′-tetramethoxy)-1,1′-biphenyl( cas:1365531-93-6 ) is researched.COA of Formula: C52H60O4P2.Lin, Shaoquan; Kawato, Yuji; Kumagai, Naoya; Shibasaki, Masakatsu published the article 《Catalytic Asymmetric Mannich-Type Reaction of N-Alkylidene-α-Aminoacetonitrile with Ketimines》 about this compound( cas:1365531-93-6 ) in Angewandte Chemie, International Edition. Keywords: copper catalyst stereoselective Mannich reaction alkylidene aminoacetonitrile ketimine; diamine stereoselective preparation; Mannich reaction; asymmetric catalysis; copper; ketimines; nitriles. Let’s learn more about this compound (cas:1365531-93-6).
Optically active vicinal diamines are versatile chiral building blocks in organic synthesis. A soft Lewis acid/hard Bronsted base cooperative catalyst allows for an efficient stereoselective coupling of N-alkylidene-α-aminoacetonitrile and ketimines to access this class of compounds bearing consecutive tetra- and trisubstituted stereogenic centers. The strategic use of a soft Lewis basic thiophosphinoyl group for ketimines is the key to promoting the reaction, and aliphatic ketimines serve as suitable substrates with as little as 3 mol % catalyst loading.
Here is a brief introduction to this compound(1365531-93-6)COA of Formula: C52H60O4P2, if you want to know about other compounds related to this compound(1365531-93-6), you can read my other articles.
Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica