Product Details of 83435-58-9. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Boc-D-Prolinol, is researched, Molecular C10H19NO3, CAS is 83435-58-9, about Discovery of Leukotriene A4 Hydrolase Inhibitors Using Metabolomics Biased Fragment Crystallography. Author is Davies, Douglas R.; Mamat, Bjorn; Magnusson, Olafur T.; Christensen, Jeff; Haraldsson, Magnus H.; Mishra, Rama; Pease, Brian; Hansen, Erik; Singh, Jasbir; Zembower, David; Kim, Hidong; Kiselyov, Alex S.; Burgin, Alex B.; Gurney, Mark E.; Stewart, Lance J..
We describe a novel fragment library termed fragments of life (FOL) for structure-based drug discovery. The FOL library includes natural small mols. of life, derivatives thereof, and biaryl protein architecture mimetics. The choice of fragments facilitates the interrogation of protein active sites, allosteric binding sites, and protein-protein interaction surfaces for fragment binding. We screened the FOL library against leukotriene A4 hydrolase (LTA4H) by X-ray crystallog. A diverse set of fragments including derivatives of resveratrol, nicotinamide, and indole were identified as efficient ligands for LTA4H. These fragments were elaborated in a small number of synthetic cycles into potent inhibitors of LTA4H representing multiple novel chemotypes for modulating leukotriene biosynthesis. Anal. of the fragment-bound structures also showed that the fragments comprehensively recapitulated key chem. features and binding modes of several reported LTA4H inhibitors.
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Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica