With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.69812-29-9,2-Acetamido-4-methylthiazole-5-sulfonyl chloride,as a common compound, the synthetic route is as follows.
[00217] A solution of 3-(10,l l-dihydro-5H-dibenzo[?/]azepin-5-yl)propan-l-amine hydrochloride (0.075 g, 0.259 mmol) in DMF (0.85 mL) was cooled to 0 C, treated with Et3N (0.144 mL, 1.03 mmol), and 2-acetamido-4-methylthiazole-5-sulfonyl chloride (0.073 g, 0.285 mmol). The mixture was warmed to 25 C and stirred for 2 h. The mixture was partitioned between water (50 mL) and CH2CI2 (50 mL). The organic layer was washed with saturated aqueous NaCl (5 x 30 mL), dried (Na2S04), and concentrated in vacuo. The residue was dissolved in a minimal amount of CH2CI2 and purified by flash chromatography (S1O2, 2-5% ethyl acetate -hexanes) to afford the title compound (0.032 g, 26%) as a white solid. 1H NMR (600 MHz, CD3OD) delta 7.10- 7.01 (6H, m), 6.88-6.85 (2H, m), 3.71 (2H, t, J= 6.6 Hz), 3.02 (3H, br s), 2.99 (2H, J = 6.6 Hz), 2.36 (3H, s), 2.23 (3H, s), 1.71 (2H, quintet, J= 6.6 Hz); 13C NMR (150 MHz, CD3OD) delta 169.8, 159.2, 151.7, 148.2, 134.2, 129.5, 126.1, 12.4, 119.6, 119.5, 46.9, 40.5, 31.9, 27.2, 21.2, 15.0; LCMS m/z 471.2135 ([M + H+], C23H27N4O3S2 requires 471.1519).
69812-29-9, As the paragraph descriping shows that 69812-29-9 is playing an increasingly important role.
Reference£º
Patent; MT. SINAI SCHOOL OF MEDICINE; OHLMEYER, Michael; NARLA, Goutham; DHAWAN, Neil; KASTRINSKY, David; WO2013/25882; (2013); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica