The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-Aminopyrrole-2-carboxamide( cas:159326-69-9 ) is researched.Electric Literature of C5H7N3O.Sampognaro, Anthony J.; Wittman, Mark D.; Carboni, Joan M.; Chang, Chiehying; Greer, Ann F.; Hurlburt, Warren W.; Sack, John S.; Vyas, Dolatrai M. published the article 《Proline isosteres in a series of 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitors of IGF-1R kinase and IR kinase》 about this compound( cas:159326-69-9 ) in Bioorganic & Medicinal Chemistry Letters. Keywords: isosteric proline replacement pyrrolo triazine inhibitor IGF1R kinase structure. Let’s learn more about this compound (cas:159326-69-9).
Pyrrolidine, pyrrolidinone, carbocyclic, and acyclic groups were used as isosteric proline replacements in a series of insulin-like growth factor I receptor kinase/insulin receptor kinase inhibitors. Examples that were similar in potency to proline-containing reference compounds were shown to project a key fluoropyridine amide into a common space, while less potent compounds were not able to do so for reasons of stereochem. or structural rigidity.
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Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica