78502-71-3,78502-71-3, Ethyl 2-(bromomethyl)thiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Preparation Example 26; 3-Phenylpropan-1-amine (11.33 g) and potassium carbonate (11.58 g) were added to acetonitrile (300 mL), and MeOH and a solution of ethyl 2-(bromomethyl)-1,3-thiazole-4-carboxylate (11.64 g) in acetonitrile (30 mL) in an ice bath were slowly added dropwise thereto, followed by stirring at room temperature for about 1 hour. To the reaction mixture was added an appropriate amount of ice water, followed by extraction with ethyl acetate several times. The organic layer was washed with brine and dried over MgSO4, and then the solvent was concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (ethyl acetate_hexane=3:1 to 5:1) to prepare ethyl 2-{[(3-phenylpropyl)amino]methyl}-1,3-thiazole-4-carboxylate (13.17 g).
The synthetic route of 78502-71-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Astellas Pharma Inc.; US2012/184521; (2012); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica