The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Boc-D-Prolinol( cas:83435-58-9 ) is researched.Reference of Boc-D-Prolinol.Arnold, Kenny; Batsanov, Andrei S.; Davies, Bryan; Grosjean, Christophe; Schuetz, Thorben; Whiting, Andrew; Zawatzky, Kerstin published the article 《The first example of enamine-Lewis acid cooperative bifunctional catalysis: application to the asymmetric Aldol reaction》 about this compound( cas:83435-58-9 ) in Chemical Communications (Cambridge, United Kingdom). Keywords: pyrrolidine butoxycarbonyl derivative sparteine lithiation pinacol chloromethylboronate alkylation deprotection; homoboroproline bifunctional enamine Lewis acid catalyst preparation crystal structure; nitrobenzaldehyde acetone tartrate ester homoboroproline catalyst Aldol addition; Aldol adduct stereoselective preparation. Let’s learn more about this compound (cas:83435-58-9).
(-)-Sparteine directed lithiation of N-Boc-pyrrolidine, alkylation with chloromethylboronate pinacol ester and acid-based deprotection provides homoboroproline I HX salt in 94% ee. Salts of I are shown to be efficient enamine-type pyrrolidine catalysts in an asym. aldol reaction when neutralized, and especially when esterified in situ with a tartrate ester, for example, providing 90% ee of the aldol adduct derived from acetone and p-nitrobenzaldehyde.
In some applications, this compound(83435-58-9)Reference of Boc-D-Prolinol is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica