So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Carocci, Alessia; Lentini, Giovanni; Catalano, Alessia; Cavalluzzi, Maria Maddalena; Bruno, Claudio; Muraglia, Marilena; Colabufo, Nicola Antonio; Galeotti, Nicoletta; Corbo, Filomena; Matucci, Rosanna; Ghelardini, Carla; Franchini, Carlo researched the compound: Boc-D-Prolinol( cas:83435-58-9 ).Product Details of 83435-58-9.They published the article 《Chiral Aryloxyalkylamines: selective 5-HT1B/1D Activation and Analgesic Activity》 about this compound( cas:83435-58-9 ) in ChemMedChem. Keywords: serotonin agonist 5HT1b 5HT1d analgesic aryloxyalkylamine SAR preparation. We’ll tell you more about this compound (cas:83435-58-9).
A series of chiral 2,3-dichlorophenoxy and 1-naphthyloxy alkylamines were synthesized, and their binding affinities towards 5-HT1D and h5-HT1B receptors were evaluated. In the naphthyloxy series, the (R)-prolinol derivative was the most selective 5-HT1D ligand, while (S)-N-methyl-2-(1-naphthyloxy)propan-1-amine showed the highest selectivity for h5-HT1B. Both compounds performed as 5-HT1D agonists in the isolated guinea pig assay and showed higher analgesic activity than both sumatriptan and the achiral analog 20 b (I) in the mouse hot-plate test. Neither ligand displayed any affinity for nicotinic ACh receptors present in mouse brain membranes, thus indicating that their analgesic activity does not arise through interaction with these receptors.
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Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica