In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Gold Nanoparticle Promoted Formation and Biological Properties of Injectable Hydrogels, published in 2020-09-14, which mentions a compound: 111-18-2, mainly applied to hydrogel gold nanoparticle, COA of Formula: C10H24N2.
Acceleration of gelation in the biol. environment and improvement of overall biol. properties of a hydrogel is of enormous importance. Biopolymer stabilized gold (Au) nanoparticles (NPs) exhibit cytocompatibility and therapeutic activity. Hence, in situ gelation and subsequent improvement in the property of a hydrogel by employing Au NPs is an attractive approach. We report that stable Au NPs accelerate the conventional nucleophilic substitution reaction of activated halide-terminated poly(ethylene glycol) and tertiary amine functional macromols., leading to the rapid formation of injectable nanocomposite hydrogels in vivo and ex vivo with improved modulus, cell adhesion, cell proliferation, and cytocompatibility than that of a pristine hydrogel. NP surfaces with low chain grafting d. and good colloidal stability are crucial requirements for the use of these NPs in the hydrogel formation. Influence of the structure of the amine functional prepolymer, the spacer connecting the halide leaving groups of the substrate, and the structure of the stabilizer on the rate promoting activity of the NPs have been evaluated with model low-mol.-weight substrates and macromols. by 1H NMR spectroscopy, rheol. experiments, and d. functional theory. Results indicate a significant effect of the spacer connecting the halide leaving group with the macromol. The Au nanocomposite hydrogels show sustained co-release of methotrexate, an anti-rheumatic drug, and the Au NPs. This work provides insights for designing an injectable nanocomposite hydrogel system with multifunctional property. The strategy of the use of cytocompatible Au NPs as a promoter provides new opportunity to obtain an injectable hydrogel system for biol. applications.
If you want to learn more about this compound(N1,N1,N6,N6-Tetramethylhexane-1,6-diamine)COA of Formula: C10H24N2, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(111-18-2).
Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica