Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Bioorganic & Medicinal Chemistry Letters called Design, synthesis, and evaluation of imidazo[4,5-c]pyridin-4-one derivatives with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γ, Author is Casimiro-Garcia, Agustin; Heemstra, Ronald J.; Bigge, Christopher F.; Chen, Jing; Ciske, Fred A.; Davis, Jo Ann; Ellis, Teresa; Esmaeil, Nadia; Flynn, Declan; Han, Seungil; Jalaie, Mehran; Ohren, Jeffrey F.; Powell, Noel A., which mentions a compound: 18232-91-2, SMILESS is NC1=C(N)C(C)=CN=C1Cl, Molecular C6H8ClN3, Related Products of 18232-91-2.
Identification of a series of imidazo[4,5-c]pyridin-4-one derivatives, e.g., I and II, that act as dual angiotensin II type 1 (AT1) receptor antagonists and peroxisome proliferator-activated receptor-γ (PPARγ) partial agonists is described. Starting from a known AT1 antagonist template, conformational restriction was introduced by incorporation of an indane ring that when combined with appropriate substitution at the imidazo[4,5-c]pyridin-4-one provided a novel series possessing the desired dual activity. The mode of interaction of this series with PPARγ was corroborated through the X-ray crystal structure of I bound to the human PPARγ ligand binding domain. Modulation of activity at both receptors through substitution at the pyridone nitrogen led to the identification of potent dual AT1 antagonists/PPARγ partial agonists. Among them, II was identified possessing potent dual pharmacol. (AT1 IC50 = 7 nM; PPARγ EC50 = 295 nM, 27% max) and good ADME properties.
There is still a lot of research devoted to this compound(SMILES：NC1=C(N)C(C)=CN=C1Cl)Related Products of 18232-91-2, and with the development of science, more effects of this compound(18232-91-2) can be discovered.
Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica