In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Discovery of Leukotriene A4 Hydrolase Inhibitors Using Metabolomics Biased Fragment Crystallography, published in 2009-08-13, which mentions a compound: 83435-58-9, mainly applied to leukotriene hydrolase inhibitor drug discovery metabolomics crystallog structure activity; drug screening leukotriene hydrolase inhibitor preparation structure activity crystallog, Computed Properties of C10H19NO3.
We describe a novel fragment library termed fragments of life (FOL) for structure-based drug discovery. The FOL library includes natural small mols. of life, derivatives thereof, and biaryl protein architecture mimetics. The choice of fragments facilitates the interrogation of protein active sites, allosteric binding sites, and protein-protein interaction surfaces for fragment binding. We screened the FOL library against leukotriene A4 hydrolase (LTA4H) by X-ray crystallog. A diverse set of fragments including derivatives of resveratrol, nicotinamide, and indole were identified as efficient ligands for LTA4H. These fragments were elaborated in a small number of synthetic cycles into potent inhibitors of LTA4H representing multiple novel chemotypes for modulating leukotriene biosynthesis. Anal. of the fragment-bound structures also showed that the fragments comprehensively recapitulated key chem. features and binding modes of several reported LTA4H inhibitors.
There is still a lot of research devoted to this compound(SMILES：O=C(N1[C@@H](CO)CCC1)OC(C)(C)C)Computed Properties of C10H19NO3, and with the development of science, more effects of this compound(83435-58-9) can be discovered.
Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica