Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 159326-69-9, is researched, SMILESS is O=C(C1=CC=CN1N)N, Molecular C5H7N3OJournal, RSC Advances called Copper(II)-catalyzed cascade approach for the synthesis of pyrrolo[2,1-f][1,2,4]triazine-fused isoquinolines, Author is Chen, Jianyang; Liu, Bo; Chen, Yanhong; He, Qian; Yang, Chunhao, the main research direction is pyrrolo triazine fused isoquinoline one pot tandem regioselective preparation; alkynylbenzaldehyde amino pyrrolecarboxamide condensation nucleophilic addition cyclization copper catalyst.Application In Synthesis of 1-Aminopyrrole-2-carboxamide.
A copper(II)-catalyzed coupling-cyclization reaction that allowed a facile access to an impressive variety of pyrrolo[2,1-f][1,2,4]triazine-fused isoquinolines, e.g., I, in good to excellent yields has been developed. The reaction proceeded with high 6-endo-dig regioselectivity, and the product was confirmed by x-ray crystallog. study. This method appeared to be compatible with different substituted starting materials that have different electronic properties, increasing its applicability to various functional groups.
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Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica