With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10200-59-6,2-Thiazolecarboxaldehyde,as a common compound, the synthetic route is as follows.
General procedure: Method A [31]: To a solution of the starting aldehyde (1.5 mmol) and ketone (0.75 mmol) in methanol (10 mL) was added the solution of sodium methoxide in methanol (5.4 M, 0.14 mL,0.75 mmol), and the mixture was stirred for 4-18 h and monitored with TLC. When the reaction was completed, the following two work-up procedures were applied. Procedure 1: if precipitate was observed, the precipitate was filtered and rinsed with cold methanol. Procedure 2: if no precipitate was observed, then saturated solution of ammonium chloride was added, and the subsequent mixture was extracted with dichloromethane. The organic layer was dried over anhydrous MgSO4. The solvent was evaporated under vacuum to give a crude product, which was purified by preparative TLC (3e5percent methanol in dichloromethane) or column chromatography (2percent methanol in dichloromethane)., 10200-59-6
As the paragraph descriping shows that 10200-59-6 is playing an increasingly important role.
Reference£º
Article; Samaan, Nawras; Zhong, Qiu; Fernandez, Jayjoel; Chen, Guanglin; Hussain, Ali M.; Zheng, Shilong; Wang, Guangdi; Chen, Qiao-Hong; European Journal of Medicinal Chemistry; vol. 75; (2014); p. 123 – 131;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica