The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Boc-D-Prolinol(SMILESS: O=C(N1[C@@H](CO)CCC1)OC(C)(C)C,cas:83435-58-9) is researched.Quality Control of 2,6-Dimethyl-3,5-heptanedione. The article 《Cobalt-Catalyzed Alkylation of Drug-Like Molecules and Pharmaceuticals Using Heterocyclic Phosphonium Salts》 in relation to this compound, is published in ACS Catalysis. Let’s take a look at the latest research on this compound (cas:83435-58-9).
Alkylated pyridines are common in pharmaceuticals, and metal catalysis is frequently used to prepare this motif via Csp2-Csp3 coupling processes. We present a cobalt-catalyzed coupling reaction between pyridine phosphonium salts and alkylzinc reagents that can be applied to complex drug-like fragments and for late-stage functionalization of pharmaceuticals. The reaction generally proceeds at room temperature, and 4-position pyridine C-H bonds are the precursors in this strategy. Given the challenges in selectively installing (pseudo)halides in complex pyridines, this two-step process enables sets of mols. to be alkylated that would be challenging using traditional cross-coupling methods.
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Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica