Related Products of 83435-58-9. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Boc-D-Prolinol, is researched, Molecular C10H19NO3, CAS is 83435-58-9, about Chemistry and Pharmacological Studies of 3-Alkoxy-2,5-Disubstituted-Pyridinyl Compounds as Novel Selective α4β2 Nicotinic Acetylcholine Receptor Ligands That Reduce Alcohol Intake in Rats. Author is Liu, Yong; Richardson, Janell; Tran, Thao; Al-Muhtasib, Nour; Xie, Teresa; Yenugonda, Venkata Mahidhar; Sexton, Hannah G.; Rezvani, Amir H.; Levin, Edward D.; Sahibzada, Niaz; Kellar, Kenneth J.; Brown, Milton L.; Xiao, Yingxian; Paige, Mikell.
Neuronal acetylcholine receptors mediate the addictive effects of nicotine and may also be involved in alc. addiction. Varenicline, an approved smoking cessation medication, showed clear efficacy in reducing alc. consumption in heavy-drinking smokers. More recently, sazetidine-A, which selectively desensitizes α4β2 nicotinic receptors, was shown to significantly reduce alc. intake in a rat model. To develop novel therapeutics for treating alc. use disorder, we designed and synthesized novel sazetidine-A analogs containing a Me group at the 2-position of the pyridine ring. In vitro pharmacol. studies revealed that some of the novel compounds showed overall pharmacol. property profiles similar to that of sazetidine-A but exhibited reduced agonist activity across all nicotinic receptor subtypes tested. In rat studies, compound I significantly reduced alc. uptake. More importantly, preliminary results from studies in a ferret model indicate that these novel nAChR ligands have an improved adverse side-effect profile in comparison with that of varenicline.
In addition to the literature in the link below, there is a lot of literature about this compound(Boc-D-Prolinol)Related Products of 83435-58-9, illustrating the importance and wide applicability of this compound(83435-58-9).
Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica