Extracurricular laboratory: Synthetic route of 83435-58-9

In addition to the literature in the link below, there is a lot of literature about this compound(Boc-D-Prolinol)Formula: C10H19NO3, illustrating the importance and wide applicability of this compound(83435-58-9).

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Angst, Daniela; Gessier, Francois; Janser, Philipp; Vulpetti, Anna; Walchli, Rudolf; Beerli, Christian; Littlewood-Evans, Amanda; Dawson, Janet; Nuesslein-Hildesheim, Barbara; Wieczorek, Grazyna; Gutmann, Sascha; Scheufler, Clemens; Hinniger, Alexandra; Zimmerlin, Alfred; Funhoff, Enrico G.; Pulz, Robert; Cenni, Bruno researched the compound: Boc-D-Prolinol( cas:83435-58-9 ).Formula: C10H19NO3.They published the article 《Discovery of LOU064 (Remibrutinib), a Potent and Highly Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase》 about this compound( cas:83435-58-9 ) in Journal of Medicinal Chemistry. Keywords: LOU064 remibrutinib Bruton tyrosine kinase inhibitor autoimmune diseases antiinflammatory. We’ll tell you more about this compound (cas:83435-58-9).

Bruton’s tyrosine kinase (BTK), a cytoplasmic tyrosine kinase, plays a central role in immunity and is considered an attractive target for treating autoimmune diseases. The use of currently marketed covalent BTK inhibitors is limited to oncol. indications based on their suboptimal kinase selectivity. We describe the discovery and preclin. profile of LOU064 (remibrutinib, 25), a potent, highly selective covalent BTK inhibitor. LOU064 exhibits an exquisite kinase selectivity due to binding to an inactive conformation of BTK and has the potential for a best-in-class covalent BTK inhibitor for the treatment of autoimmune diseases. It demonstrates potent in vivo target occupancy with an EC90 of 1.6 mg/kg and dose-dependent efficacy in rat collagen-induced arthritis. LOU064 is currently being tested in phase 2 clin. studies for chronic spontaneous urticaria and Sjoegren’s syndrome.

In addition to the literature in the link below, there is a lot of literature about this compound(Boc-D-Prolinol)Formula: C10H19NO3, illustrating the importance and wide applicability of this compound(83435-58-9).

Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica