Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2,5-Diphenyloxazole, is researched, Molecular C15H11NO, CAS is 92-71-7, about Silver-Induced [3+2] Cycloaddition of Isocyanides with Acyl Chlorides: Regioselective Synthesis of 2,5-Disubstituted Oxazoles.Safety of 2,5-Diphenyloxazole.
A silver-induced cycloaddition of isocyanides with acyl chlorides were developed. This transition metal-catalyzed strategy provided an effective and scalable approach for the formation of 2,5-disubstituted oxazoles in good to high yields. The employed silver-based MOF catalyst can be efficiently recycled without compromising the yield.
In addition to the literature in the link below, there is a lot of literature about this compound(2,5-Diphenyloxazole)Safety of 2,5-Diphenyloxazole, illustrating the importance and wide applicability of this compound(92-71-7).
Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica