Safety of Boc-D-Prolinol. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Boc-D-Prolinol, is researched, Molecular C10H19NO3, CAS is 83435-58-9, about Synthesis and Stereochemical Assignment of Conioidine A: DNA- and HSA-Binding Studies of the Four Diastereomers. Author is Shaktah, Ryan; Vardanyan, Laura; David, Elroma; Aleman, Alexis; Orr, Dupre; Shaktah, Lawrence A.; Tamae, Daniel; Minehan, Thomas.
Conioidine A, I, isolated in 1993 with unknown relative and absolute configuration, was suggested to be a DNA-binding compound by an indirect technique. Four stereoisomers of conioidine A have been synthesized from D- and L-proline, and the natural product has been identified as possessing (4R,6R) absolute configuration. Binding of the conioidine diastereomers to calf thymus DNA (CT DNA) and human serum albumin (HSA) has been investigated by fluorescence spectroscopy and isothermal titration calorimetry (ITC). All stereoisomers display at least an order of magnitude weaker binding to DNA than the control compound netropsin; however, a strong association with HSA was observed for the (4R,6S) stereoisomer. Preliminary anticancer activity was assessed against MCF-7 cells.
This literature about this compound(83435-58-9)Safety of Boc-D-Prolinolhas given us a lot of inspiration, and I hope that the research on this compound(Boc-D-Prolinol) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica