7305-71-7, 2-Amino-5-methylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Comparative Example 1 Synthesis of 2-chloro-5-methylthiazole In a 300 ml volume three necked flask equipped with a stirrer, a dropping funnel and a thermometer, 20 g of 2-amino5-methylthiazole (0.175 mol), 35 ml of 36% hydrochloric acid (0.407 mol) and 30 ml of water were placed and cooled to -5 C. To the mixture, 14 g of sodium nitrite (0.203 mol) dissolved in 30 ml of water was gradually added dropwise at 0 C. or lower. The reaction mixture was further caused to react for three hours at 0 C. or lower to give the diazonium base. The reaction mixture was heated to 80 C. for three hours and extracted with three 40 ml portions of chloroform to give a chloroform solution containing 2-chloro-5-methylthiazole. The chloroform was removed by atmospheric distillation and remained fraction was distilled under reduced pressure to isolate 10.3 g of 2-chloro-5-methylthiazole (0.077 mol) with a yield of 44%., 7305-71-7
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Reference£º
Patent; Kureha Chemical Industry Co., Ltd.; US5811555; (1998); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica