Taylor Ringia, Erika A.; Tyler, Peter C.; Evans, Gary B.; Furneaux, Richard H.; Murkin, Andrew S.; Schramm, Vern L. published the article 《Transition State Analogue Discrimination by Related Purine Nucleoside Phosphorylases》. Keywords: transition state analog active site purine nucleoside phosphorylase.They researched the compound: Boc-D-Prolinol( cas:83435-58-9 ).COA of Formula: C10H19NO3. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:83435-58-9) here.
Transition state analogs of PNP, the Immucillins and DADMe-Immucillins, were designed to match transition state features of bovine and human PNPs, resp. The inhibitors with or without the hydroxyl and hydroxymethyl groups of the substrate demonstrate that inhibitor geometry mimicking that of the transition state confers binding affinity discrimination. This finding is remarkable since crystallog. anal. indicates complete conservation of active site residues and contacts to ligands in human and bovine PNPs.
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Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica