Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, ACS Catalysis called Cobalt-Catalyzed Alkylation of Drug-Like Molecules and Pharmaceuticals Using Heterocyclic Phosphonium Salts, Author is Zhang, Xuan; McNally, Andrew, which mentions a compound: 83435-58-9, SMILESS is O=C(N1[C@@H](CO)CCC1)OC(C)(C)C, Molecular C10H19NO3, Recommanded Product: Boc-D-Prolinol.
Alkylated pyridines are common in pharmaceuticals, and metal catalysis is frequently used to prepare this motif via Csp2-Csp3 coupling processes. We present a cobalt-catalyzed coupling reaction between pyridine phosphonium salts and alkylzinc reagents that can be applied to complex drug-like fragments and for late-stage functionalization of pharmaceuticals. The reaction generally proceeds at room temperature, and 4-position pyridine C-H bonds are the precursors in this strategy. Given the challenges in selectively installing (pseudo)halides in complex pyridines, this two-step process enables sets of mols. to be alkylated that would be challenging using traditional cross-coupling methods.
When you point to this article, it is believed that you are also very interested in this compound(83435-58-9)Recommanded Product: Boc-D-Prolinol and due to space limitations, I can only present the most important information.
Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica