With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.78485-37-7,Ethyl 2-chloro-6-benzothiazolecarboxylate,as a common compound, the synthetic route is as follows.
To ethyl 2-chlorobenzo[d]thiazole-6-carboxylate (1d-1) (305 mg, 1.263 mmol) and (1R,3R,5S)-N-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methyl)-8-azabicyclo[3.2.1]octan-3-amine hydrochloride (1c-1) (430 mg, 0.842 mmol, ?84% by weight) in DMA (5 ml) was added cesium carbonate (686 mg, 2.105 mmol). The resulting mixture was heated up to 60 C. for 16 h, cooled down to room temperature. The mixture was diluted with ethyl acetate, washed with water (4*), brine, dried, filtered, and concentrated. The residue was chromatographed by CombiFlash eluting with hexane to 70% ethyl acetate/hexane to give ethyl 2-((1R,3R,5S)-3-(((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methyl)amino)-8-azabicyclo[3.2.1]octan-8-yl)benzo[d]thiazole-6-carboxylate (Example 1) (198 mg). LC/MS observed [M+H], 597.15.
As the paragraph descriping shows that 78485-37-7 is playing an increasingly important role.
Reference£º
Patent; Enanta Pharmaceuticals, Inc.; Ma, Jun; Wang, Guoqiang; Wang, Bin; Xing, Xuechao; Shen, Ruichao; He, Jing; Or, Yat Sun; (530 pag.)US2018/99957; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica