In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis and evaluation of in vivo anti-hypothermic effect of all stereoisomers of the thyrotropin-releasing hormone mimetic: Rovatirelin Hydrate, published in 2019, which mentions a compound: 83435-58-9, mainly applied to TRH mimetic rovatirelin stereoisomers antihypothermic effect SAR; TRH; TRH mimetic; anti-hypothermic effect; intravenous administration; rovatirelin; stereoisomers, Computed Properties of C10H19NO3.
We discovered the orally active TSH-releasing hormone (TRH) mimetic: (4S,5S)-5-methyl-N-{(2S)-1-[(2R)-2-methylpyrrolidin-1-yl]-1-oxo-3-(1,3-thiazol-4-yl)propan-2-yl}-2-oxo-1,3-oxazolidine-4-carboxamide 1 (rovatirelin). The central nervous system (CNS) effect of rovatirelin after i.v. (iv) administration is 100-fold higher than that of TRH. As 1 has four asym. carbons in its mol., there are 16 stereoisomers. We synthesized and evaluated the anti-hypothermic effect of all stereoisomers of 1, which has the (4S),(5S),(2S),(2R) configuration from the N-terminus to the C-terminus, in order to clarify the structure-activity relationship (SAR) of stereoisomers. The (4R),(5R),(2R),(2S)-isomer 16 did not show any anti-hypothermic effect. Only the (4S),(5S),(2S),(2S)-isomer 10, which has the (2S)-2-methylpyrrolidine moiety at the C-terminus showed the anti-hypothermic effect similar to 1. Stereoisomers, which have the (5R) configuration of the oxazolidinone at the N-terminus and the (2R) configuration at the middle-part, showed a much lower anti-hypothermic effect than that of 1. On the other hand, stereoisomers, which have the (4R) configuration of the oxazolidinone at the N-terminus or the (2S) configuration of the C-terminus, have little influence on the anti-hypothermic effect.
Compounds in my other articles are similar to this one(Boc-D-Prolinol)Computed Properties of C10H19NO3, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.
Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica