With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.121-66-4,5-Nitrothiazol-2-amine,as a common compound, the synthetic route is as follows.
N- (5-Nitro-1, 3-thiazol-2-yl) pentanamide To a solution of 2-amino-5-nitrothiazole (205 mg, 1.41 mmol) and triethylamine (271 muL, 2.11 mmol) in methylene chloride (25 mL) was added dropwise n-valeroylchloride (180 pL, 1.48 mmol). The reaction solution was stirred over night and washed with a saturated sodium bicarbonate solution. The layers were separated and the organic layer was dried with sodium sulfate, filtered and concentrated. The crude product was purified on a silica gel column using hexane/ethyl acetate (4: 1) as the eluent to give 130 mg (40% yield) of the title compound as a light yellow solid: mp 155-156 C ; IH NMR (CDC13, 300 MHz) 8 11.2 (br s, 1 H), 8.29 (s, 1 H), 2. 59 (t, J= 7 Hz, 2 H), 1.84-1. 74 (m, 2 H), 1. 51-1. 39 (m, 2 H), 0. 98 (t, J= 7 Hz, 3 H) ; 13C NMR (CDC13, 75 MHz) 8 171. 67,162. 02,143. 46, 139. 46, 35.98, 26.38, 22.24, 13.67 ; EIMS (70 eV) m/z (relative intensity) 229 (M+, 34), 85 (100), 57 (24)., 121-66-4
121-66-4 5-Nitrothiazol-2-amine 8486, athiazole compound, is more and more widely used in various fields.
Reference£º
Patent; ASTRAZENECA AB; WO2003/89419; (2003); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica