Quality Control of 1-Aminopyrrole-2-carboxamide. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 1-Aminopyrrole-2-carboxamide, is researched, Molecular C5H7N3O, CAS is 159326-69-9, about Synthesis of pyrrolo[2,1-f][1,2,4]triazine congeners of nucleic acid purines via the N-amination of 2-substituted pyrroles. Author is Patil, Shirish A.; Otter, Brian A.; Klein, Robert S..
The synthesis of several new 4-mono- and 2,4-disubstituted pyrrolo[2,1-f][1,2,4]triazines is described. Key intermediates 1-aminopyrrole-2-carbonitrile (3) and 1-amino-5-ethylpyrrole-2-carbonitrile (15) were obtained by N-amination of the corresponding pyrrole-2-carboxaldehyde followed by CHO → CN conversion with either hydroxylamine-O-sulfonic acid for 3 or O-mesitylenesulfonylhydroxylamine for 15. Cyclization of 3 or 15 with a variety of amidine reagents or, after conversion of 3 to its corresponding amide, base-catalyzed annulation completed the synthesis of the title products.
After consulting a lot of data, we found that this compound(159326-69-9)Quality Control of 1-Aminopyrrole-2-carboxamide can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica