With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5464-79-9,2-Amino-4-methoxybenzothiazole,as a common compound, the synthetic route is as follows.
5464-79-9, 2-Amino-4-methoxy-benzothiazole (1. 00 g, 5.54 mmol) was added to a stirred solution of polyphosphoric acid (85%, 40 ml) at 60 C. The resulting mixture was stirred at 60 C until all the benzothiazole had dissolved. The resulting solution was then cooled to-10 C and a solution of sodium nitrite (2.3 g, 33.3 mmol) in water (5 ml) was added so as to keep the internal temperature BELOW-4 C. After complete addition the resulting solution was added to a solution of hypophosphoric acid (50%, 15 ml) at 0 C. After the evolution of gas had ceased the mixture was diluted with water and basified with NAHC03 (sat). The aqueous solution was extracted with CHC13 (3 x 200 ML) with the combined organic extracts dried (MGSO4) and the solvent removed in vacuo. The resulting solid was recrystallised from EtOH: H20 to give an orange solid (300 mg). The liquor was concentrated and purified by flash chromatography eluting silica gel with hexane: EtOAc [4: 1] to hexane: EtOAc [1: 1] to give a further 210mg of product. RF = 0. 38 in hexane : ether [1 : 1] ; ON (300 MHz, CDC13) 8.91 (1H, s, CH), 7.53 (1H, d, Ar), 7.39 (1H, T, Ar), 6.93 (1H, d, Ar), 4.07 (3H, s, OCH3)
5464-79-9 2-Amino-4-methoxybenzothiazole 21622, athiazole compound, is more and more widely used in various fields.
Reference£º
Patent; ELI LILLY AND COMPANY; WO2004/43931; (2004); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica