Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 18362-64-6, is researched, Molecular C9H16O2, about Convenient Synthesis of Benzothiazoles and Benzimidazoles through Bronsted Acid Catalyzed Cyclization of 2-Amino Thiophenols/Anilines with β-Diketones, the main research direction is benzothiazole benzimidazole chemoselective preparation; cyclocondensation beta diketone aminobenzenethiol benzenediamine toluenesulfonic acid catalyst.SDS of cas: 18362-64-6.
In the presence of p-toluenesulfonic acid, diketones RCOCH2COR1 (R = R1 = Me, Et, i-Pr, Ph; R = Me; R1 = Ph) underwent cyclocondensation reactions with 2-aminobenzenethiols 4-R2-2-H2NC6H3SH (R2 = H, Cl) or 1,2-benzenediamines 4-R2-1,2-C6H3(NH2)2 (R2 = H, Cl, Me, MeO, O2N) to give benzothiazoles and benzimidazoles I (R = R1 = Me, Et, i-Pr, Ph; R2 = H, Cl, Me, MeO, O2N; X = S, NH) under either solvent-free conditions at ambient temperature or in acetonitrile at 80° without an oxidant, metal catalyst, or microwave irradiation in 51-95% yields.
After consulting a lot of data, we found that this compound(18362-64-6)SDS of cas: 18362-64-6 can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica