Millet, Antoine;Filho, Mauro Safir;Hamouda-Tekaya, Nedra;Cavazza, Elisa;Abbe, Patricia;Ruediger, Johanna;Plaisant, Magali;Mayen, Julie;Rocchi, Stephane;Ronco, Cyril;Benhida, Rachid published 《Development and in vivo evaluation of fused benzazole analogs of anti-melanoma agent HA15》. The research results were published in《Future Medicinal Chemistry》 in 2021.Application In Synthesis of 6-Nitrobenzo[d]thiazol-2-amine The article conveys some information:
In line with our recent discovery of an efficient anticancer thiazolebenzenesulfonamide framework HA15 (1) based on a remarkable endoplasmic reticulum stress inducement mode of action, we report herein a series of innovative constrained HA15 analogs, featuring four types of bicylic derivatives The structure-activity relationship anal., using a cell line assay, led us to identify a novel version of HA15: a new benzothiazole derivative (10b) exhibiting important anti-melanoma effect against sensitive and resistant melanoma cells. Meanwhile, compound 10b induced a significant tumor growth inhibition in vivo with no apparent signs of toxicity. These results consistently open new directions to improve and develop more powerful anticancer therapeutics harboring this type of fused framework. The experimental procedure involved many compounds, such as 6-Nitrobenzo[d]thiazol-2-amine (cas: 6285-57-0) .
6-Nitrobenzo[d]thiazol-2-amine(cas:6285-57-0 Application In Synthesis of 6-Nitrobenzo[d]thiazol-2-amine) is an antimicrobial agent that inhibits bacterial growth by cleaving the peptide bonds of proteins. It has been shown to be active against a number of microorganisms, including Gram-positive and Gram-negative bacteria, as well as fungi.
Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica