Addanki, Hanumantha Rao;Vallabhaneni, Madhava Rao;Chennamsett, Subramanyam;Pullagura, Priyadarshini;Sagurthi, Someswara Rao;Pasupuleti, Visweswara Rao published 《An in silico ADMET, molecular docking study and microwave-assisted synthesis of new phosphorylated derivatives of thiazolidinedione as potential anti-diabetic agents》 in 2022. The article was appeared in 《Synthetic Communications》. They have made some progress in their research.Category: thiazole The article mentions the following:
A series of new phosphorylated derivatives of thiazolidinedione was synthesized for the first time with high yields (92-96%) in short reaction time (7-15 min) by the reaction of 4-{[(5E)-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl}phenyl Et phosphorochloridate with various heterocyclic amines by microwave irradiation technique under solvent-free condition. A study on in silico ADMET and mol. docking was performed for all the mols. to acquire an insight on drug likeliness behavior and also their ability to inhibit the enzyme, α-amylase. The mols. with momentous pharmacokinetic properties with substantial binding affinity were synthesized. The synthesized compounds were characterized spectroscopically to confirm their structure and then in vitro α-amylase inhibitory activity was also carried out for all the newly prepared compounds The synthesized compounds were characterized spectroscopically to confirm their structure and then in vitro α-amylase inhibitory activity was also carried out for all the newly prepared compounds All the leftover compounds displayed modest to excellent inhibition in comparison with reference drug, Acarbose. To complete the study, the researchers used 6-Nitrobenzo[d]thiazol-2-amine (cas: 6285-57-0) .
6-Nitrobenzo[d]thiazol-2-amine(cas:6285-57-0 Category: thiazole) inhibits the activity of amines, which are small molecules found in many pharmaceuticals. The chemical structure of this drug contains one or more methylene groups that can be activated by diazonium salt to form an intermediate molecule with a reactive amine group.
Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica