Formula: C12H9N3O5S《Phenotypic screening techniques for Cryptosporidium drug discovery》 was published in 2021. The authors were Love, Melissa S.;McNamara, Case W., and the article was included in《Expert Opinion on Drug Discovery》. The author mentioned the following in the article:
A review. Two landmark epidemiol. studies identified Cryptosporidium spp. as a significant cause of diarrheal disease in pediatric populations in resource-limited countries. Notably, nitazoxanide is the only approved drug for treatment of cryptosporidiosis but shows limited efficacy. As a result, many drug discovery efforts have commenced to find improved treatments. The unique biol. of Cryptosporidium presents challenges for traditional drug discovery methods, which has inspired new assay platforms to study parasite biol. and drug screening. The authors review historical advancements in phenotypic-based assays and techniques for Cryptosporidium drug discovery, as well as recent advances that will define future drug discovery. The reliance on phenotypic-based screens and repositioning of phenotypic hits from other pathogens has quickly created a robust pipeline of potential cryptosporidiosis therapeutics. The latest advances involve new in vitro culture methods for oocyst generation, continuous culturing capabilities, and more physiol. relevant assays for testing compounds Previous phenotypic screening techniques have laid the groundwork for recent cryptosporidiosis drug discovery efforts. The resulting improved methodologies characterize compound activity, identify, and validate drug targets, and prioritize new compounds for drug development. The most recent improvements in phenotypic assays are poised to help advance compounds into clin. development. To complete the study, the researchers used 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate (cas: 55981-09-4) .
2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate(cas: 55981-09-4), an anthelmintic agent, exhibits a broad spectrum of activities against a wide variety of helminths, protozoa, and enteric bacteria infecting animals and humans.Formula: C12H9N3O5S
Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica