Application In Synthesis of 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate《Current pharmacotherapy of cryptosporidiosis: an update of the state-of-the-art》 was published in 2021. The authors were Schneider, Anne;Wendt, Sebastian;Luebbert, Christoph;Trawinski, Henning, and the article was included in《Expert Opinion on Pharmacotherapy》. The author mentioned the following in the article:
Cryptosporidiosis has emerged as a major cause of diarrheal disease worldwide. It has especially serious health consequences for young, malnourished children living in endemic areas and for individuals with highly impaired T-cell function, such as HIV-pos. individuals with low CD4 counts or immunosuppressed solid-organ transplant recipients. A selective literature search using PubMed was performed to review the available therapeutics to treat cryptosporidiosis, as well as related advances in drug development. The only FDA-approved antiparasitic treatment in immunocompetent patients is nitazoxanide; however, it has failed to demonstrate convincing effectiveness among HIV-pos. patients, immunosuppressed individuals and malnourished children. Thus, restoring HIV-pos. patients’ cellular immune response through effective antiretroviral therapy (ART), or reducing or changing immunosuppressive drugs, is important. Several new targets have been identified for chemotherapy, and the development of drugs for these targets has progressed, including parasite kinases, nucleic acid synthesis and processing, proteases and lipid metabolism Candidate drugs that have been shown to be effective and safe in a neonatal calf model will most likely constitute the next advance for clin. trials in humans. However, developing an effective and inexpensive vaccination, as well as complementing structural preventive measures, would most decisively reduce the global cryptosporidiosis burden. And 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate (cas: 55981-09-4) was used in the research process.
2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate(cas: 55981-09-4) has been approved as an orphan drug for the treatment of diarrhea in children (age, 1–11 years) and is associated with giardiasis, but it also is approved for diarrhea caused by crytosporidiosis in patients with AIDS.Application In Synthesis of 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate
Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica