71224-95-8, 2-Aminobenzo[d]thiazole-7-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
71224-95-8, Example 116, 2-amino-N-(5-(2,3-dihvdrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)benzo[d]thiazole-7-carboxamide[00153] HATU (0.201 g, 0.53 mmol) and DIPEA (0.230 mL, 1 .32 mmol) were added to a solution of 2-aminobenzo[d]thiazole-7-carboxylic acid (102 mg, 0.53 mmol) in DMA (3 mL) under an inert atmosphere and the reaction allowed to stir for 15 minutes. Compound 2 (0.125 g, 0.440 mmol) was added and the reaction stirred at ambient temperature for approximately 24 hours and then at 40 C overnight. No product was observed. Additional 2-aminobenzo[d]thiazole-7-carboxylic acid (102 mg, 0.53 mmol) was converted to the acid chloride by treatment with oxalyl chloride (approximately 1 .2 equivalents) and DMF (a few drops) in DCM and the acid chloride added to the reaction mixture. The reaction was diluted with water and the solids filtered. The solids were dissolved in DMF and purified by preparative HPLC. Fractions containing the desired compound were evaporated to dryness to afford the desired material as a white solid (0.043 g, 21 %).1H NMR (400 MHz, DMSO) delta 10.05 (s, 1 H), 10.04 (s, 1 H), 7.87 (d, J = 7.1 Hz, 1 H), 7.82 (d, J = 2.2 Hz, 1 H), 7.62 (dd, J = 2.2, 8.3 Hz, 1 H), 7.49 – 7.56 (m, 3H), 7.47 (s, 2H), 7.39 (t, J = 7.8 Hz, 1 H), 7.25 (d, J = 8.5 Hz, 1 H), 6.98 (d, J = 8.4 Hz, 1 H), 4.28 – 4.35 (m, 4H), 2.21 (s, 3H). m/z (ES+), (M+H)+ = 461 .
The synthetic route of 71224-95-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; JONES, Keith; RYE, Carl; CHESSUM, Nicola; CHEESEMAN, Matthew; PASQUA, Adele Elisa; PIKE, Kurt Gordon; FAULDER, Paul Frank; WO2015/49535; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica