With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.161798-03-4,Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate,as a common compound, the synthetic route is as follows.
172.8 g of formic acid and16.0 g of ethyl 2-(3-formyl-4-isobutoxy-phenyl)-4-methyl-thiazole-5-carboxylate (FBT-1) prepared in Example 1 were added to a 500 ml round bottom flask, 4.2g hydroxylamine hydrochloride and 4.1g sodium formate were added, and stirred at 105 ~ 110 C for 2h. After completion of the reaction, cooled to 20 ~ 30 C, heat crystallization was carried out for 1h, filtered, filter cake was washed with 25.3g ethanol, filtered, dried and 14.2 g of ethyl 2-(3-cyano-4-isobutoxy-phenyl)-4-methyl-thiazole-5-carboxylate (FBT-2) was obtained in a yield of 89.5%., 161798-03-4
The synthetic route of 161798-03-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Hunan Fangsheng Pharmaceutical Co., Ltd.; Zhang Qinghua; Chen Bo; Yan Zhiyong; (6 pag.)CN109912531; (2019); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica