131184-73-1, (2-Aminothiazol-5-yl)methanol is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a DMF (4 mL) solution of (frans)-3-(quinolin-8-yloxy)cyclobutanecarboxylic acid (Intermediate 79) (80 mg, 0.33 mmol) was added HATU (150 mg, 0.395 mmol) and N,N- diisopropylethylamine (0.17 mL, 1 .0 mmol). After 5 minutes, (2-aminothiazol-5-yl)methanol (51 .4 mg, 0.395 mmol) was added, and the mixture was stirred for 3 h, quenched with water, extracted with EtOAc, dried over Na2SC>4, filtered and concentrated. The residue was purified on silica gel, eluting with a 0%-100% EtOAc:EtOH (3:1)-hexanes gradient to give the title compound (26 mg, 21 %). 1H NMR (400 MHz, CD3SOCD3) delta 2.39-2.51 (m, 2 H), 2.79 (qd, J = 7, 5 Hz, 2 H), 3.40-3.48 (m, 1 H), 4.57 (d, J = 5 Hz, 2 H), 5.00-5.10 (m, 1 H), 5.35 (t, J = 5 Hz, 1 H), 6.97 (dd, J = 1, 2 Hz, 1 H), 7.26 (s, 1 H), 7.42-7.59 (m, 3 H), 8.29 (dd, J = 8, 2 Hz, 1 H), 8.84 (dd, J = 4, 2 Hz, 1 H), 12.00 (s, 1 H); LC-MS (LC-ES) M+H = 356.
131184-73-1, The synthetic route of 131184-73-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; DEATON, David Norman; GUO, Yu; HANCOCK, Ashley Paul; SCHULTE, Christie; SHEARER, Barry George; SMITH, Emilie Despagnet; STEWART, Eugene L.; THOMSON, Stephen Andrew; (556 pag.)WO2018/69863; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica