With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.81449-93-6,Ethyl 2-chlorothiazole-5-carboxylate,as a common compound, the synthetic route is as follows.
Dissolve ethyl 2-CHLOROTHIAZOLE-5-CARBOXYLATE (0.927 g, 4. 84 mmol) in methanol. Cool the solution to 0 C, then bubble NH3 into the reaction mixture for 10 minutes. Then seal the reaction vessel and stir for 3 hours. Concentrate the reaction mixture to give the title product : LH NMR (CDC13) : 8. 21 (s, 1H), 8.19 (s, 1H), 7.77 (s, 1H) ; HPLC [YMC-Pro pack C-18 (150 x 4.6 mm, S-5 microm), 0.05% TFA/acetonitrile in 0.05% TFA/WATER at 1.0 ML/MIN, 10-20% over 5 min, 20-95% over 18], tR = 6.9 min, 100% purity, 81449-93-6
Big data shows that 81449-93-6 is playing an increasingly important role.
Reference£º
Patent; ELI LILLY AND COMPANY; WO2004/80996; (2004); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica