Learn more about cas: 6285-57-0 | Research on Chemical Intermediates 2018

6-Nitrobenzo[d]thiazol-2-amine(cas:6285-57-0Electric Literature of C7H5N3O2S) has been shown to lower blood pressure in mice by inhibiting angiotensin converting enzyme and potassium channels. This drug also has a protective effect on the heart and brain from ischemia reperfusion injury.

Electric Literature of C7H5N3O2SIn 2018, Ahlawat, Aarti;Khatkar, Priyanka;Singh, Vikramjeet;Asija, Sonika published 《Diorganotin(IV) complexes of Schiff bases derived from salicylaldehyde and 2-amino-6-substituted benzothiazoles: synthesis, spectral studies, in vitro antimicrobial evaluation and QSAR studies》. 《Research on Chemical Intermediates》published the findings. The article contains the following contents:

In the present work, Schiff base ligands (1–4) were prepared by condensation of 2-amino-6-substituted-benzothiazole and salicylaldehyde in a 1:1 molar ratio and were further treated with diorganotindichloride R’2SnCl2 leading to a series of organotin(IV) complexes (5–20) of type R’2SnL1-4Cl [R’ = Ph, Bu, Et, Me]. The prepared Schiff base ligands and the organotin(IV) complexes were characterized by various spectroscopic techniques (1H, 13C, 119Sn NMR, FT-IR) and phys. techniques. All the synthesized compounds were evaluated for in vitro antibacterial and antifungal activity against two Gram pos. bacterial strains B. cereus, S. aureus, two Gram neg. bacterial strains E. coli, P. aeruginosa and two fungal strains A. niger and A. flavus by serial dilution method. The spectral data revealed that the complexes were pentacoordinated with bidentate ligands coordinated through oxygen and nitrogen. The results of antimicrobial activity revealed that the synthesized complexes were more toxic towards Gram pos. bacterial strains as compared to Gram neg. bacterial strains. From the results of QSAR anal., it was indicated that the antimicrobial activity of the synthesized compounds were controlled by topol. parameters (mol. connectivity indexes). To complete the study, the researchers used 6-Nitrobenzo[d]thiazol-2-amine (cas: 6285-57-0) .

6-Nitrobenzo[d]thiazol-2-amine(cas:6285-57-0Electric Literature of C7H5N3O2S) has been shown to lower blood pressure in mice by inhibiting angiotensin converting enzyme and potassium channels. This drug also has a protective effect on the heart and brain from ischemia reperfusion injury.

Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica