With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.106092-09-5,(S)-(-)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole,as a common compound, the synthetic route is as follows.
General procedure: To a solution of carboxylic acid (1 mmol) in CH2Cl2 (10 ml) were added Et3N (2 mmol) and TBTU (1.1 mmol) and the mixture was stirred at room temperature for 15 min. Then amine 1 or 3 (1 mmol)and Et3N (2 mmol) were added and the reaction mixture was stirred at room temperature for 2.5 h. The reaction mixture was diluted with CH2Cl2 (15 ml) and washed with saturated aqueous NaHCO3 solution (2×15 ml). Combined water phases were extracted with CH2Cl2 (1 20 ml). Combined organic phases weredried over Na2SO4, filtered and the solvent removed under reduced pressure.
106092-09-5, The synthetic route of 106092-09-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Hodnik, ?iga; Toma?i?, Tihomir; Ma?i?, Lucija Peterlin; Chan, Fiona; Kirby, Robert W.; Madge, David J.; Kikelj, Danijel; European Journal of Medicinal Chemistry; vol. 70; (2013); p. 154 – 164;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica