16311-69-6, 5-(2-Hydroxyethyl)-3,4-dimethylthiazol-3-ium iodide is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A mixture of 1,5-dimethyl-4-(hydroxyethyl) thiazolium iodide (2.5 mmol, 700 mg), methylsulfonyl chloride (3 mmol, 0.25 ml) and triethylamine (5 mmol, 0.35 ml) in CH3CN(20 ml) was stirred at 0 C for 2 h, under argon. After rotary evaporation, the crude product was dissolved in ethanol (25 ml). Potassium thioacetate (3 mmol, 343 mg) was added dropwise and the mixture was allowed to reflux for 72 h. The product mixture was rotary evaporated to dryness, then the resultant crude solid was dissolved in formic acid (5 ml). Performic acid was generated by stirring hydrogen peroxide (14 mmol, 1.8 ml) and formic acid (30 mmol, 1.4 ml) at room temperature for 1 h. The performic acid solution was cooled to 0 C and added to the reaction mixture. The mixture was left stirring for 48 h. Excess solvent was removed by rotary evaporation and the final crude product was purified by HPLC. 1H NMR (300 MHz,DMSO-d6) delta 9.90 (s, H), 4.05 (s, 3 H), 3.14-3.19 (t, J = 7.1 Hz, 2 H),2.70-2.75 (t, J = 7.0 Hz, 2 H), 2.41 (s, 3 H).
16311-69-6, 16311-69-6 5-(2-Hydroxyethyl)-3,4-dimethylthiazol-3-ium iodide 9838770, athiazole compound, is more and more widely used in various fields.
Reference£º
Article; Zeng, Hao; Wang, Kai; Tian, Yuan; Niu, Yijie; Greene, Landon; Hu, Zhichao; Lee, Jeehiun K.; International Journal of Mass Spectrometry; vol. 378; (2015); p. 169 – 174;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica