Yevtodiyenko, Aleksey; Bazhin, Arkadiy; Khodakivskyi, Pavlo; Godinat, Aurelien; Budin, Ghyslain; Maric, Tamara; Pietramaggiori, Giorgio; Scherer, Sandra S.; Kunchulia, Marina; Eppeldauer, George; Polyakov, Sergey V.; Francis, Kevin P.; Bryan, Jeffrey N.; Goun, Elena A. published the artcile< Portable bioluminescent platform for in vivo monitoring of biological processes in non-transgenic animals>, Name: (S)-2-(6-Hydroxybenzo[d]thiazol-2-yl)-4,5-dihydrothiazole-4-carboxylic acid, the main research area is bioluminescent transgenic animal biol process invivo monitoring.
Bioluminescent imaging (BLI) is one of the most powerful and widely used preclin. imaging modalities. However, the current technol. relies on the use of transgenic luciferase-expressing cells and animals and therefore can only be applied to a limited number of existing animal models of human disease. Here, we report the development of a “”portable bioluminescent”” (PBL) technol. that overcomes most of the major limitations of traditional BLI. We demonstrate that the PBL method is capable of noninvasive measuring the activity of both extracellular (e.g., dipeptidyl peptidase 4) and intracellular (e.g., cytochrome P 450) enzymes in vivo in non-luciferase-expressing mice. Moreover, we successfully utilize PBL technol. in dogs and human cadaver, paving the way for the translation of functional BLI to the noninvasive quantification of biol. processes in large animals. The PBL methodol. can be easily adapted for the noninvasive monitoring of a plethora of diseases across multiple species.
Nature Communicationspublished new progress about Animal gene, CYP3A Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 2591-17-5 belongs to class thiazole, and the molecular formula is C11H8N2O3S2, Name: (S)-2-(6-Hydroxybenzo[d]thiazol-2-yl)-4,5-dihydrothiazole-4-carboxylic acid.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica