With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.155559-81-2,5-Fluorobenzo[d]thiazole-2-thiol,as a common compound, the synthetic route is as follows.
Example 40Preparation of7V,7V-dicyclopropyl-6-ethyl-4-(5-fluorobenzo[d]thiazol-2-ylamino)-l- methyl-l,6-dihydroimidazo [4,5-d] pyrrolo [2,3-b] pyridine-7-carboxamide 40A Preparation of 5-fluoro-2- methylthio)benzo|”d”lthiazole[00284] To a solution of 5-fluoro-2-mercaptobenzothiazole (0.15 g, 0.810 mmol) in THF (8.10 niL) cooled to 0 C was added sodium hydride (0.036 g, 0.891 mmol). After stirring 10 min, iodomethane (0.076 mL, 1.215 mmol) was added and the reaction mixture was slowly warmed to room temperature over 2 h. The reaction was diluted with ethyl acetate and quenched with saturated aqueous sodium bicarbonate. The organic layer was washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. 5-fluoro-2-(methylthio)benzo[d]thiazole (0.178 g, 110 % yield) was isolated as a white solid. Material was used without any further purification.[00285] MS (ESI) m/z 200.0 (M+H)[00286] 1H NMR (400 MHz, CHLOROFORM-d) delta ppm 7.68 (dd, 1H, J= 8.81, 5.04 Hz), 7.56 (dd, 1H, J= 9.57, 2.52 Hz), 7.07 (td, 1H, J= 8.81, 2.52 Hz), 2.80 (s, 3H), 155559-81-2
The synthetic route of 155559-81-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; PURANDARE, Ashok V.; GREBINSKI, James W.; HART, Amy; INGHRIM, Jennifer; SCHROEDER, Gretchen; WAN, Honghe; WO2011/28864; (2011); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica