Tungen, Joern E.; Aursnes, Marius; Hansen, Trond Vidar published the artcile< Stereoselective synthesis of maresin 1>, Application of C10H11NS2, the main research area is maresin 1 stereoselective preparation diastereoselective Evans Nagao aldol.
Maresin 1 (I) is a potent anti-inflammatory and pro-resolving lipid mediator derived from docosahexaenoic acid. The total synthesis of maresin 1 is achieved in 10 steps and in 7% overall yield. The Evans-Nagao aldol reaction between (2E,4E)-5-bromopenta-2,4-dienal and different chiral auxiliaries is investigated. The reported synthesis is efficient and highly stereoselective, affording multi-milligram quantities of this biol. interesting lipid mediator.
Tetrahedron Letters published new progress about Aldol addition, stereoselective. 171877-39-7 belongs to class thiazole, and the molecular formula is C10H11NS2, Application of C10H11NS2.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica